b'ADVANCING KNOWLEDGE THROUGH DATARESEARCH HIGHLIGHTSCARES continues to support groundbreaking research that advances cardiac arrest understanding, shapes policy, and drives improvements in patient outcomes. Highlighted here are two recent studies leveraging CARES data to inform change at local, state, and national levels.Building a Statewide Cardiac Arrest Registry Utilizing CARES infrastructureBy Michelle Nassal, MD, PhD Assistant Professor of Emergency Medicine, The Ohio State University; Troy Acker, NRP Ohio CARES State Coordinator; Justin Benoit, MD Associate Professor of Emergency Medicine, University of CincinnatiCardiac arrest remains a leading cause of morbidity and mortality nationwide. The American Heart Association (AHA) guidelines emphasize the importance of community-based systems to improve outcomes from cardiac arrest. A key component of these systems is the development of a structured regional database, which facilitates continuous monitoring and feedback to individual EMS agencies. More broadly, the establishment of a structured regional database can guide systemwide improvements and enable more effective resource allocation across the region. There were temporal increases in ROSC (29.7% to 31.9%, p=0.028), survival (7.4% to 12.3%, p0.001) and survival with good neurologic outcome (5.6% to 8.6%, p=0.047). The organized statewide implementation of CARES in Ohio was associated with significant increases in community uptake and observed improvements in patient outcomes.28Figure 1. Temporal Trends in Ohio CARES EMS Agency Participation.'