b'2021 CARES Annual Report 45 45 Another example of how CARES data has highlighted opportunities to improve survival outcomes in high-risk communities involves the potential use of drones to quickly deliver an AED to bystanders at the scene of a witnessed OHCA. While timely use of an AED is known to dramatically improve the chances of survival, the demographic makeup and other essential features of a community predict OHCA treatment variability and may influence whether bystanders can and will rapidly and successfully apply an AED for defibrillation. A pilot program currently underway in North Carolina aims to explore the association of community phenotypic clusters on current OHCA treatment patterns in high OHCA-incidence communities and assess the need of an emergency drone network within the community.19The studies and interventions featured above demonstrate the value of surveillance and monitoring data in identifying high-risk populations and unmet needs, tailoring interventions to meet those needs, and evaluating the effectiveness of initiatives to improve OHCA response at the community level. Systematic implementation of evidence-based, quality improvement initiatives coupled with focused community engagement and surveillance can improve survival outcomes in systems with historically low OHCA survival rates. Using 2021 CARES data, the table below shows key OHCA interventions and outcomes by patient race/ethnicity and gender, as well as by neighborhood racial composition and median household income. CARES data both reflects the trends highlighted in the above-mentioned studies and identifies additional high-risk populations for future studies and interventions. CARES data shows a strong correlation between the racial composition of the neighborhood in which an OHCA occurs and patient outcomes - majority White ( 70%) neighborhoods had the highest survival rate (9.7%), neighborhoods with large Black populations ( 40%) had the lowest survival rate (7.5%), and integrated neighborhoods had intermediate patient outcomes (9.0%). Similarly, bystander CPR provision and public AED use were consistently associated with both neighborhood racial composition and median household income. These data highlight the importance of investing in underserved communities to promote better patient outcomes and an increase in the use of key interventions such as bystander CPR and AED use.Table. Differences in Bystander Interventions and Survival After OHCA, by Race/Ethnicity, Gender, and Neighborhood Characteristics, CARES 2021. 19Starks MA, Sperling J, Cardenas A, Blewer AL, Sharpe E, Buckland DM, Joiner A, Zegre-Hemsey J, Mark DB. Barriers and Opportunities for a Drone-Delivered AED Network in Durham, North Carolina. American Heart Association Resuscitation Symposium, 2020 November 14-15; Virtual.'